6-Amino-2-(4-fluorophenyl)-4-methoxy-3- (4-pyridyl)-1H-pyrrolo[2, 3-b]pyridine (RWJ 68354): a potent and selective p38 kinase inhibitor

J Med Chem. 1998 Oct 22;41(22):4196-8. doi: 10.1021/jm980497b.

Authors

J R Henry¹, K C Rupert, J H Dodd, I J Turchi, S A Wadsworth, D E Cavender, B Fahmy, G C Olini, J E Davis, J L Pellegrino-Gensey, P H Schafer, J J Siekierka

Affiliation

¹ The R.W. Johnson Pharmaceutical Research Institute, 1000 Route 202, Raritan, New Jersey 08869, USA.

PMID: 9784093
DOI: 10.1021/jm980497b

No abstract available

MeSH terms

Aminopyridines / pharmacology*
Animals
Arthritis, Experimental / pathology
Calcium-Calmodulin-Dependent Protein Kinases / antagonists & inhibitors*
Enzyme Inhibitors / pharmacology*
Humans
In Vitro Techniques
Interleukin-1 / antagonists & inhibitors
Lipopolysaccharides
Male
Mice
Mice, Inbred BALB C
Mitogen-Activated Protein Kinases*
Monocytes / drug effects
Monocytes / metabolism
Pyrroles / pharmacology*
Rats
Rats, Inbred Lew
T-Lymphocytes / drug effects
T-Lymphocytes / metabolism
Tumor Necrosis Factor-alpha / antagonists & inhibitors
p38 Mitogen-Activated Protein Kinases

Substances

Aminopyridines
Enzyme Inhibitors
Interleukin-1
Lipopolysaccharides
Pyrroles
RWJ 68354
Tumor Necrosis Factor-alpha
Calcium-Calmodulin-Dependent Protein Kinases
Mitogen-Activated Protein Kinases
p38 Mitogen-Activated Protein Kinases